Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Identifieur interne : 001F76 ( Main/Exploration ); précédent : 001F75; suivant : 001F77Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Auteurs : Ali Moh Zaki [Arabie saoudite] ; Sander Van Boheemen [Pays-Bas] ; Theo M. Bestebroer [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Ron A. M. Fouchier [Pays-Bas]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Arabie saoudite.
- topic : Homme, Adulte, Médecine.
English descriptors
- KwdEn :
Abstract
A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Affiliations:
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Le document en format XML
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Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Coronavirus</term><term>Human</term><term>Isolation</term><term>Male</term><term>Medicine</term><term>Pneumonia</term><term>Saudi Arabia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pneumonie</term><term>Isolement</term><term>Coronavirus</term><term>Homme</term><term>Mâle</term><term>Adulte</term><term>Arabie saoudite</term><term>Médecine</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Adulte</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Moh Zaki, Ali" sort="Moh Zaki, Ali" uniqKey="Moh Zaki A" first="Ali" last="Moh Zaki">Ali Moh Zaki</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Boheemen, Sander Van" sort="Boheemen, Sander Van" uniqKey="Boheemen S" first="Sander Van" last="Boheemen">Sander Van Boheemen</name></region><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M." last="Bestebroer">Theo M. Bestebroer</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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